Nefiracetam is an effective nootropic supplement that has been developed in Japan. It is a member of the racetam family and acts by stabilizing pathways that connect neurons in the brain. It is known to boost the brain’s concentration and memory systems.
The bulk materials for slurrying experiments were prepared through a slurry crystallization in ethyl acetate (room temperature overnight) and the resulting solid phases were retrieved and analyzed.
Nefiracetam powder europe is a nootropic of the racetam family that is believed to help improve memory and cognitive functions by changing the levels of the inhibitory neurotransmitter GABA in your brain. It also increases the amount of acetylcholine, which is involved in synaptic transmission and plasticity. It is also known to enhance long-term potentiation in the brain and improve learning ability.
It’s also a good cholinergic compound that helps in increasing the availability of the neurotransmitter acetylcholine in your frontal cortex, which has a direct effect on memory and learning. It has been shown to increase your attention spans and focus as well.
In addition, it has been shown to have antidementia properties and may even be beneficial in treating Alzheimer’s disease. It also has a very low toxicity and is safe to take in higher doses. The molecule contains the pyrrolidone nucleus that is common to all racetams and easily crosses the blood-brain barrier. It has a high affinity for the GABA-A receptor and increases the density of acetylcholine in the frontal cortex, which in turn promotes cognition.
The solubility and dissolution rate of Nefiracetam were compared to those of three hitherto unknown cocrystal forms. These new cocrystals were obtained with biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride and have been fully structurally characterized. The bulk material for dissolution experiments was prepared by slurrying the compounds overnight in ethyl acetate at room temperature and subsequently dried.
Slow cooling of the supersaturated solution yielded suitable monoclinic C2/c cube-like single crystals of the anhydrate. The structure was solved showing that the acetam molecules are coordinated to the zinc chloride in a tetragonal geometry around the Zn2+ ion.
The crystalline form of FI is stable over a week at ambient temperature and pressure. Upon heating, it forms a second polymorph FII and is only soluble in hygroscopic organic solvents. XRPD measurements reveal the transitions between these two polymorphic forms and show that they have different dissolution rates.
Nefiracetam powder is fat-soluble and rapidly enters the brain once consumed. It boosts acetylcholine production and enhances memory, learning ability and focus. It can be used alone or in combination with choline supplements, including CDP-Choline and Alpha GPC. It has neuroprotective properties, and may help reduce memory loss in people with Alzheimer’s or other types of dementia caused by cerebrovascular problems.
Compared to piracetam, it’s more potent in improving spatial learning and memory retention, and is also effective at enhancing attention spans. The recommended dosage for Nefiracetam is 100 – 900 mg per day, taken in divided doses throughout the day.
Bulk material was prepared for dissolution testing through slurrying experiments by placing excess amounts of FI and monohydrate in different solvents. During this process, vials were sealed and left for three days at 25 degC stirring at 700 rpm with a Cooling Thermomixer HLC manufactured by Ditabis. The slurry was subsequently melted and the solid phases were retrieved for analysis.
Nefiracetam is non-toxic and safe to supplement with long-term. Side effects are typically mild and are associated with low doses taken for prolonged periods of time. The most common side effect reported is headaches, which can be resolved by taking a high-quality choline supplement with the nootropic.
Nefiracetam works to increase the activity of the cholinergic and monoaminergic neuronal systems in the brain which are important for memory formation and focus. It also improves long-term potentiation and boosts learning.
It is a fat-soluble racetam compound similar to piracetam and aniracetam, but it has more affinity for the acetylcholine receptors of neurons in the human brain. It has been shown to enhance the formation of memories when supplemented over a prolonged period of time in animal studies. It is reported to reduce apathy in stroke patients, and this was confirmed in a clinical trial with 137 stroke survivors who were treated with either nefiracetam or placebo.